Study Design & Methodological Issues

Title Type Size
A Guide for the Design and Conduct of Self-Administered Surveys of Clinicians pdf 178 KB Download
A Practical Guide to Surveys and Questionnaires pdf 146 KB Download
A Practical Guide to Understanding Systematic Reviews and Meta Analyses pdf 248 KB Download
A Primer in Longitudinal Data Analysis pdf 429 KB Download
Allocation Concealment pdf 171 KB Download
Allocation Concealment versus Blinding in Randomised Controlled Trials pdf 208 KB Download
Blinding in Clinical Trials and Other Studies pdf 55 KB Download
Case Control Studies: Advantages and Disadvantages pdf 215 KB Download
Clinical Significance versus Statistical Significance pdf 214 KB Download
Cluster Randomised Controlled Trials pdf 174 KB Download
Concealing Treatment Allocation in Randomised Trials pdf 111 KB Download
Confounding in Clinical Trials pdf 180 KB Download
Controlled Trials pdf 207 KB Download
Crossover Trials pdf 169 KB Download
Cross-Sectional Studies: Advantages and Disadvantages pdf 211 KB Download
Emerging Trends in Clinical Trial Design pdf 129 KB Download
Equivalence Trials pdf 197 KB Download
Essential Elements of Questionnaire Design and Development pdf 109 KB Download
External and Internal Validity in Clinical Trials pdf 175 KB Download
Good Practice in the Conduct and Reporting of Survey Research pdf 90 KB Download
How to Conduct a Randomized Trial pdf 124 KB Download
How to Design a Randomized Controlled Trial pdf 159 KB Download
Interaction Revisited: The Difference Between Two Estimates pdf 193 KB Download
Meta Analyses: Sources of Bias pdf 169 KB Download
Meta Analysis in Medical Research pdf 795 KB Download
Meta Analysis: Neither Quick Nor Easy pdf 287 KB Download
Missing Outcomes in Randomised Trials pdf 208 KB Download
Nested Case Control Studies: Advantages and Disadvantages pdf 217 KB Download
Observational Studies and Predictive Models pdf 976 KB Download
Observational Study Design pdf 176 KB Download
Observational Study Design II pdf 178 KB Download
Observational Study Designs pdf 191 KB Download
Open Clinical Trials pdf 167 KB Download
Placebo Controlled Trials pdf 215 KB Download
Prospective Cohort Studies: Advantages and Disadvantages pdf 218 KB Download
Quality Not Just Quantity: The Role of Qualitative Methods in Anesthesia Research pdf 60 KB Download
Questionnaire Surveys pdf 170 KB Download
Randomised Controlled Trials with Full Factorial Designs pdf 173 KB Download
Randomised Controlled Trials: Internal versus External Validity pdf 213 KB Download
Randomized Controlled Trials: Part 17 of a Series on Evaluation of Scientific Publications pdf 260 KB Download
Review Article: Medical Education Research - An Overview of Methods pdf 287 KB Download
Screening pdf 348 KB Download
Selection Bias versus Allocation Bias pdf 185 KB Download
Sham Treatments pdf 208 KB Download
SPIRIT 2013 Statement: Defining Standard Protocol Items for Clinical Trials pdf 138 KB Download
Statistical Analysis of Correlated Data Using Generalized Estimating Equations: An Orientation pdf 1979 KB Download
Stratified Random Allocation pdf 175 KB Download
Study Design in Medical Research pdf 244 KB Download
Systematic Literature Reviews and Meta Analyses pdf 451 KB Download
Systematic Reviews: The Case for Rigorous Methods and Rigorous Reporting pdf 838 KB Download
The Hawthorne Effect pdf 170 KB Download
The Placebo Effect pdf 166 KB Download
The Purpose of Control Groups pdf 173 KB Download
Treatment Allocation by Minimisation pdf 47 KB Download
Treatment Allocation in Trials: Block Randomisation pdf 222 KB Download
Tutorial in Biostatistics Using the General Linear Mixed Model to Analyse Unbalanced Repeated Measures and Longitudinal Data pdf 410 KB Download
Tutorials in Clinical Research Part III: Selecting a Research Approach to Best Answer a Clinical Question pdf 140 KB Download
Tutorials in Clinical Research Part IV: Recognizing and Controlling Bias pdf 132 KB Download
Types of Study in Medical Research pdf 366 KB Download
Undertaking a Literature Review: A Step-by-Step Approach pdf 115 KB Download
Validating Scales and Indexes pdf 105 KB Download
What is a Crossover Trial pdf 214 KB Download
What is a Superiority Trial pdf 214 KB Download
Why Match in Case Control Studies pdf 173 KB Download
Why Randomise in Clinical Trials pdf 175 KB Download
Zelen S Design pdf 181 KB Download

Statistical Notes

Title Type Size
A Practical Guide for Understanding Confidence Intervals and P Values pdf 437 KB Download
A Practical Guide to Understanding Systematic Reviews and Meta Analyses pdf 248 KB Download
Absence of Evidence is Not Evidence of Absence pdf 233 KB Download
Absolute and Relative Risks pdf 177 KB Download
Analysing Case Control Studies: Adjusting for Confounding pdf 193 KB Download
Analysing Controlled Trials with Baseline and Follow Up Measurements pdf 195 KB Download
Basic Statistics for Clinicians 1: Hypothesis Testing pdf 3295 KB Download
Basic Statistics for Clinicians 2: Interpreting Study Results - Confidence Intervals pdf 1419 KB Download
Basic Statistics for Clinicians 3: Assessing the Effects of Treatment - Measures of Association pdf 3916 KB Download
Basic Statistics for Clinicians 4: Correlation and Regression pdf 3465 KB Download
Bayesians and Frequentists pdf 91 KB Download
Checklist for Statistical Topics in Anesthesia Analgesia Reviews pdf 620 KB Download
Choosing Statistical Tests pdf 278 KB Download
Clinical Tests: Sensitivity and Specificity pdf 90 KB Download
Clinical Trials: Units of Randomisation pdf 209 KB Download
Cohen's Coefficient K pdf 182 KB Download
Comparing Several Groups Using Analysis of Variance pdf 362 KB Download
Comparisons within randomised groups can be very misleading pdf 192 KB Download
Confidence Interval or P Value pdf 179 KB Download
Confidence Intervals and Statistical Significance pdf 168 KB Download
Confidence Intervals and Statistical Significance: Rules of Thumb pdf 178 KB Download
Convenience Sampling pdf 208 KB Download
Data Analysis of Epidemiological Studies pdf 327 KB Download
Descriptive Statistics pdf 391 KB Download
Diagnostic Tests 1: Sensitivity and Specificity pdf 176 KB Download
Diagnostic Tests 3: Receiver Operating Characteristic Plots pdf 200 KB Download
Diagnostic Tests 4: Likelihood Ratios pdf 85 KB Download
Effect Sizes pdf 180 KB Download
Equivalence and Noninferiority Testing in Anesthesiology Research pdf 370 KB Download
Essential Elements of Questionnaire Design and Development pdf 109 KB Download
Estimating the Mean and Variance from the Median Range and the Size of Sample pdf 529 KB Download
Generalisation and Extrapolation of Study Results pdf 176 KB Download
Hazards and Hazard Ratios pdf 172 KB Download
How to Calculate Sample Size in Randomized Controlled Trials pdf 411 KB Download
How to Obtain the Confidence Interval from a P Value pdf 179 KB Download
How to Read a Forest Plot pdf 269 KB Download
Incidence Rates pdf 168 KB Download
Interaction 3: How to Examine Heterogeneity pdf 233 KB Download
Judging a Plethora of p-Values pdf 279 KB Download
Kaplan Meier Survival Curves: Interpretation and Communication of Risk pdf 263 KB Download
Logistic Regression pdf 186 KB Download
Measurement Method Comparison pdf 778 KB Download
Meta Analyses: Heterogeneity and Subgroup Analysis pdf 475 KB Download
Meta Analyses: How to Read a Funnel Plot pdf 204 KB Download
Meta Analyses: Standardised Mean Differences pdf 612 KB Download
Meta Analyses: Tests of Heterogeneity pdf 300 KB Download
Missing Data pdf 57 KB Download
Multiple Regression pdf 188 KB Download
Multiple Significance Tests: The Bonferroni Method pdf 218 KB Download
Non-Parametric Statistical Tests for Independent Groups - Numerical Data pdf 178 KB Download
Non-Parametric Statistical Tests for Two Independent Groups - Numerical Data pdf 209 KB Download
Number Needed to Harm pdf 168 KB Download
Odds and Odds Ratios pdf 211 KB Download
One Way Analysis of Variance pdf 181 KB Download
P Values or Confidence intervals? pdf 179 KB Download
Parametric Statistical Tests for Independent Groups: Numerical Data pdf 182 KB Download
Parametric Statistical Tests for Two Related Groups: Numerical Data pdf 217 KB Download
Parametric v Non Parametric Statistical Tests pdf 177 KB Download
Pearson's Correlation coefficient pdf 310 KB Download
Practical Guide to Choosing an Appropriate Data Display pdf 279 KB Download
Practical Guide to Understanding Multivariable Analyses: Part A pdf 242 KB Download
Practical Guides to Understanding Sample Size and Minimal Clinically-Important Difference (MCID) pdf 395 KB Download
Presentation of Numerical Data pdf 192 KB Download
Quartiles, Quintiles, Centiles and Other Quantities pdf 202 KB Download
Receiver Operating Characteristic Curves pdf 214 KB Download
Regression Towards the Mean pdf 184 KB Download
Relative Risks versus Odds Ratios pdf 216 KB Download
Sample Size Calculation in Clinical Trials pdf 256 KB Download
Sample Size Calculations in Randomised Trials: Mandatory and Mystical pdf 899 KB Download
Sample Size Calculations: Basic Principles and Common Pitfalls pdf 665 KB Download
Sample Size Calculations: Should the Emperor's Clothes Be Off the Peg or Made to Measure? pdf 232 KB Download
Sample Size for Beginners pdf 2200 KB Download
Sample Size: How Many Participants are Needed in a Trial pdf 183 KB Download
Simple Linear Regression pdf 217 KB Download
Standard Deviations and Standard Errors pdf 62 KB Download
Statistical and Clinical Significance and How to Use Confidence Intervals to Help Interpret Both pdf 129 KB Download
Statistical Guidelines for Contributors to Medical Journals pdf 2975 KB Download
Statistical Pearls III: The Most Likely Interpretation pdf 575 KB Download
Statistical Reviewing for Medical Journals pdf 117 KB Download
Statistical Tests for Independent Groups: Categorical Data pdf 179 KB Download
Statistical Tests for Independent Groups: Time to Event Data pdf 175 KB Download
Statistics and Ethics in Medical Research VIII: Improving the Quality of Statistics in Medical Journals pdf 2447 KB Download
Statistics at Square One III: Standard Deviation pdf 963 KB Download
Statistics for the Reader: What to Ask Before Believing the Results pdf 48 KB Download
Statistics I: Data and Correlations pdf 246 KB Download
Statistics II: Central Tendency and Spread of Data pdf 123 KB Download
Statistics III: Probability and Statistical Tests pdf 113 KB Download
Statistics in Anaesthesia - Part I: Anaesthesia Tutorial of the Week pdf 629 KB Download
Statistics IV: Interpreting the Results of Statistical Tests pdf 132 KB Download
Statistics V: Introduction to Clinical Trials and Systematic Reviews pdf 106 KB Download
Statistics: A Brief Overview pdf 234 KB Download
Study Design in Clinical Research: Sample Size Estimation and Power Analysis pdf 1649 KB Download
Survival Analysis pdf 294 KB Download
The Cost of Dichotomising Continuous Variables pdf 44 KB Download
The Importance of Statistical Power pdf 218 KB Download
The Normal Distribution pdf 249 KB Download
Time to Event (survival) Data pdf 428 KB Download
Transformations Means and Confidence Intervals pdf 201 KB Download
Tutorial in Biostatistics Meta Analysis: Formulating, Evaluating, Combining and Reporting pdf 587 KB Download
Tutorial in Biostatistics: Handling Drop-Out in Longitudinal Studies pdf 447 KB Download
Tutorials in Clinical Research Part VII: Understanding Comparative Statistics (contrast) | Part A - General Concepts of Statistical Significance pdf 290 KB Download
Using the General Linear Mixed Model to Analyse Unbalanced Repeated Measures and Longitudinal Data pdf 410 KB Download
Variables Sample Estimates and Population Parameters pdf 167 KB Download
VII: Statements of Probability pdf 1067 KB Download
VIII: Differences Between Means pdf 932 KB Download
What Are Odds? pdf 176 KB Download
What is a P Value? pdf 182 KB Download
What is Intention to Treat Analysis pdf 173 KB Download
What is Meta Analysis pdf 209 KB Download
What is Number Needed to Treat (NNT) pdf 180 KB Download
What is Standard Error of the Mean? pdf 181 KB Download
XI: The t Tests pdf 1061 KB Download
XIII - The t Tests pdf 848 KB Download
XIV: The Chi Tests pdf 1018 KB Download
XVII: Some Non-Parametric Tests pdf 1587 KB Download

Writing Tips & Important Guidelines

Title Type Size
A Guide to Writing Case Reports for the Journal of Medical Case Reports and Biomed Central Research Notes pdf 270 KB Download
Basic Structure and Types of Scientific Papers pdf 173 KB Download
Bias in Clinical Trials pdf 171 KB Download
Bridging Clinical Investigators and Statisticians: Writing the Statistical Methodology for a Research Proposal pdf 139 KB Download
How to Write a Case Report for Publication pdf 121 KB Download
How to Write a Good Abstract for a Scientific Paper or Conference Presentation pdf 1754 KB Download
How to Write a Scientific Paper: Writing the Methods Section pdf 161 KB Download
How to Write the Methods Section of a Research Paper pdf 250 KB Download
How to Write Your First Research Paper pdf 448 KB Download
Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research pdf 94 KB Download
Invited Commentary: How to Write a Scientific Article pdf 291 KB Download
It's Still Plagiarism pdf 346 KB Download
Optimizing Scholarly Communication: 30 Tips for Writing Clearly pdf 2353 KB Download
Preferred Reporting Items for Systematic Reviews and Meta Analyses: The PRISMA Statement pdf 165 KB Download
Preparing a Manuscript for Submission pdf 174 KB Download
Preparing Effective Illustrations Part 1: Graphs pdf 427 KB Download
Preparing Effective Illustrations Part 2: Photographs, Images and Diagrams pdf 1896 KB Download
Randomised Controlled Trials: Evaluating and Communicating Treatment Effects pdf 214 KB Download
Reporting Guidelines for Survey Research: An Analysis of Published Guidance and Reporting Practices pdf 265 KB Download
Review Article: Reporting Guidelines in the Biomedical Literature pdf 214 KB Download
Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: Guidelines for Reporting Observational Studies pdf 173 KB Download
The Case for Structuring the Discussion of Scientific Papers pdf 111 KB Download
The CONSORT Statement: Revised Recommendations for Improving the Quality Reports of Parallel Group Randomized Trials pdf 119 KB Download
Title and Title Page pdf 170 KB Download
Writing a Case Report pdf 249 KB Download
Writing a Systematic Review pdf 209 KB Download
Writing for Publication: A Guide for New Authors pdf 75 KB Download
Writing the Discussion pdf 197 KB Download
Writing the Results pdf 167 KB Download